Opportunity Information: Apply for RFA MH 22 190
The National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH), released this R01 funding opportunity (RFA-MH-22-190) to build stronger, more practical evidence on how to improve HIV outcomes by directly addressing social and structural determinants of health (SDoH/SSDoH). The central focus is HIV health inequity reduction: supporting implementation research that not only tests whether interventions work in real-world settings, but also examines how to implement them effectively, at scale, in ways that close persistent gaps across populations and communities affected by structural barriers. The FOA is positioned to generate results that travel beyond a single project site, producing generalizable lessons that can guide future programs, influence policy and guidelines, and serve as a model for other jurisdictions trying to reduce HIV disparities.
This opportunity specifically emphasizes collaborative implementation science and the use of efficient hybrid effectiveness-implementation designs. In practical terms, applicants are expected to study both outcomes at once: (1) whether SDoH-informed interventions improve HIV-related endpoints, and (2) what implementation strategies best support adoption, fidelity, sustainability, and equitable reach of those interventions within routine service systems. Because it is labeled “Clinical Trial Required,” proposed projects are expected to include a clinical trial component as defined by NIH, meaning the study prospectively assigns human participants (or clusters/sites) to an intervention to evaluate effects on health-related or behavioral outcomes. The intent is to move beyond purely descriptive work and fund projects that actively test change strategies in real service environments.
The FOA seeks a set of projects or “collaboratives” that target high-impact, real-world problems driving HIV inequities, such as barriers linked to housing instability, transportation, food insecurity, stigma and discrimination, criminal-legal involvement, immigration-related barriers, structural racism, limited access to culturally responsive care, and other systemic conditions that shape HIV prevention and treatment outcomes. Successful projects are expected to pair SDoH/SSDoH-encompassing interventions with implementation strategies that make those interventions workable within clinics, community organizations, public health systems, or cross-sector partnerships. The overall expectation is that the research will clarify what works, for whom, in what contexts, and what it takes to implement and sustain those approaches equitably.
Eligibility is broad and includes many common domestic applicant types: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities. The FOA also calls out additional eligible applicant categories that align with equity and community engagement goals, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. At the same time, there are clear restrictions: non-domestic (non-U.S.) entities (foreign organizations and foreign institutions) are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components as defined by NIH policy are not allowed.
Administratively, the opportunity is a discretionary grant using the NIH R01 mechanism, listed under CFDA numbers 93.242 and 93.279, with NIH as the awarding agency and NIMH as the sponsoring institute. The posting indicates an original closing date of 2022-11-18 and a creation date of 2022-07-20. The public summary does not specify an award ceiling or expected number of awards in the extracted fields provided, but the core emphasis is on funding multiple implementation research efforts that collectively strengthen the evidence base and produce practical guidance for jurisdictions seeking to reduce HIV inequities through interventions that tackle social and structural drivers alongside clinical and behavioral HIV services.Apply for RFA MH 22 190
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Expanding Collaborative Implementation Science to Address Social and Structural Determinants of Health and Improve HIV Outcomes (R01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.279.
- This funding opportunity was created on 2022-07-20.
- Applicants must submit their applications by 2022-11-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH R01 funding opportunity (RFA-MH-22-190) released by the National Institute of Mental Health (NIMH), part of the National Institutes of Health (NIH). It supports implementation research to reduce HIV health inequities by directly addressing social and structural determinants of health (SDoH/SSDoH) and improving real-world HIV outcomes.
What is the main goal of the FOA?
The central goal is HIV health inequity reduction. Projects are expected to generate practical, generalizable evidence on how to improve HIV outcomes by addressing social and structural drivers and by identifying effective ways to implement and sustain these approaches in routine service settings.
What types of research does the FOA prioritize?
The FOA emphasizes collaborative implementation science and efficient hybrid effectiveness-implementation designs. Applicants are expected to study both intervention impact on HIV-related endpoints and the implementation strategies needed to support adoption, fidelity, sustainability, and equitable reach.
Does the FOA require a clinical trial?
Yes. The opportunity is labeled "Clinical Trial Required." Proposed projects are expected to include a clinical trial component as defined by NIH, meaning the study prospectively assigns human participants (or clusters/sites) to an intervention to evaluate effects on health-related or behavioral outcomes.
What does NIH mean by prospectively assigning participants (or clusters/sites)?
Based on the description provided, the project is expected to actively test change strategies by assigning people or groups/sites (such as clinics or communities) to an intervention condition and evaluating effects on outcomes, rather than only observing or describing existing practices.
Is purely descriptive or observational work responsive to this FOA?
The intent is to move beyond purely descriptive work. The FOA is aimed at projects that actively test interventions and implementation strategies in real service environments and evaluate their effects.
What outcomes are applicants expected to study?
Projects are expected to study outcomes in two areas at the same time: (1) whether SDoH-informed interventions improve HIV-related endpoints, and (2) which implementation strategies best support adoption, fidelity, sustainability, and equitable reach within routine service systems.
What kinds of barriers or determinants does the FOA want projects to address?
The FOA highlights high-impact real-world problems driving HIV inequities, including housing instability, transportation barriers, food insecurity, stigma and discrimination, criminal-legal involvement, immigration-related barriers, structural racism, limited access to culturally responsive care, and other systemic conditions that shape HIV prevention and treatment outcomes.
What is meant by social and structural determinants of health (SDoH/SSDoH) in this FOA?
In this FOA, SDoH/SSDoH refers to social and structural conditions that create barriers or unequal access to resources and services, contributing to persistent gaps in HIV prevention and treatment outcomes across populations and communities.
What kinds of interventions are expected?
Successful projects are expected to pair interventions that encompass SDoH/SSDoH with implementation strategies that make those interventions workable in real-world settings (such as clinics, community organizations, public health systems, or cross-sector partnerships).
What are "implementation strategies" in the context of this FOA?
Implementation strategies are the methods used to support uptake and successful use of an intervention in routine practice. The FOA specifically calls out strategies that support adoption, fidelity, sustainability, and equitable reach.
What does the FOA mean by "hybrid effectiveness-implementation designs"?
As described in the summary, hybrid designs are expected to evaluate both whether an intervention works (effectiveness) and how best to implement it (implementation) within routine service systems, rather than addressing these questions separately.
What does "collaborative implementation science" mean here?
The FOA emphasizes collaborative approaches and mentions "collaboratives" as a set of projects. Based on the provided information, this signals an expectation that projects will be designed for real-world adoption and may involve partnerships across service systems or sectors to address structural barriers affecting HIV outcomes.
What settings are considered relevant for these projects?
The FOA references routine service environments such as clinics, community organizations, public health systems, and cross-sector partnerships as relevant settings for testing interventions and implementation strategies.
What does the FOA expect in terms of equity?
The FOA is centered on closing persistent gaps across populations and communities affected by structural barriers. Projects should examine how interventions and implementation approaches can achieve equitable reach and reduce HIV disparities.
How should projects handle generalizability and usefulness beyond a single site?
The FOA is positioned to produce results that travel beyond a single project site. The expectation is generalizable lessons that can guide future programs, influence policy and guidelines, and serve as a model for other jurisdictions seeking to reduce HIV inequities.
Who is the awarding agency and which NIH institute is sponsoring?
NIH is the awarding agency, and NIMH is the sponsoring institute for this opportunity.
What grant mechanism is used?
This opportunity uses the NIH R01 mechanism and is described as a discretionary grant.
What are the CFDA numbers listed for this opportunity?
The opportunity is listed under CFDA numbers 93.242 and 93.279.
Who is eligible to apply?
Eligibility is broad and includes (as listed): state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other entities.
Are community-based and faith-based organizations eligible?
Yes. The FOA specifically calls out faith-based or community-based organizations among eligible applicant categories.
Are minority-serving institutions (MSIs) and similar institutions eligible?
Yes. The FOA highlights several categories aligned with equity and community engagement goals, including Alaska Native and Native Hawaiian Serving Institutions, AANAPISIs, Hispanic-serving Institutions, HBCUs, and TCCUs.
Are U.S. territories eligible?
Yes. The FOA mentions U.S. territories or possessions as eligible applicant categories.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included among the additional eligible applicant categories called out in the FOA.
Are foreign (non-U.S.) organizations eligible to apply?
No. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, are not eligible to apply.
Can a U.S. organization include a non-domestic component?
No. Non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
What is the FOA number?
The FOA is RFA-MH-22-190.
What are the dates listed in the posting?
The public summary indicates a creation date of 2022-07-20 and an original closing date of 2022-11-18.
Is an award ceiling or the expected number of awards provided?
No. The extracted fields provided in the public summary do not specify an award ceiling or the expected number of awards.
What is the overall deliverable or expected contribution of funded projects?
Collectively, projects are expected to strengthen the evidence base for reducing HIV inequities by addressing social and structural drivers, while producing practical guidance that can inform programs, policy, and guidelines and help other jurisdictions implement and sustain effective approaches.
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