Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed) | RFA OD 22 013

Opportunity Information: Apply for RFA OD 22 013

The NIH Office of Research Infrastructure Programs (ORIP) is offering an R24 grant opportunity focused on building and strengthening research resources that the wider biomedical community can use, specifically animal models of human disease and closely related materials, data resources, and tools. The program is designed for projects that develop new animal models, significantly improve or better characterize existing models, expand access to information or datasets generated from animal model use, or enhance the diagnosis, prevention, and control of diseases that affect laboratory animals. A key theme is that these outputs should function as shared, broadly useful infrastructure rather than serving a single lab or a narrow scientific niche.

A central requirement is breadth of impact across NIH. The animal model, material, or technology being proposed has to be broadly applicable to the scientific priorities of at least two NIH Institutes or Centers, not just one, and it should address diseases and biological processes that involve multiple body systems. ORIP is looking for resources that can advance research across multiple disciplines and disease areas, so applications are expected to make a clear, evidence-based case for why the resource is needed, who in the community will use it, and how it will accelerate or improve research in more than one NIH mission area. Projects that are tightly focused on one specific disease, one limited research area, or a single Institute or Center's priorities are specifically discouraged and may be deemed nonresponsive. Similarly, proposals that mainly fit one NIH Institute or Center and only loosely connect to others are not considered a good match for this announcement.

This funding opportunity is titled "Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed)" and is listed as RFA-OD-22-013 under CFDA 93.351. The funding mechanism is a grant (R24), categorized under health-related research infrastructure and resource development, and it explicitly does not allow clinical trials. The emphasis is on resource creation, improvement, and dissemination rather than conducting clinical intervention studies.

Eligibility is broad and includes many types of U.S.-based organizations such as state, county, and municipal governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible applicant categories, including Historically Black Colleges and Universities, Hispanic-serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions, as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. At the same time, there are important limits on non-U.S. participation: non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply, although foreign components are allowed when they meet the NIH Grants Policy Statement definition and requirements.

The opportunity is administered by the National Institutes of Health, with an original closing date listed as 2025-05-25 and a creation date of 2022-09-09. The award ceiling and expected number of awards are not specified in the provided details, which usually means applicants need to consult the full funding announcement for budget expectations, typical award sizes, project period limits, and any special review criteria tied to resource-sharing plans, dissemination strategies, or community adoption. Overall, this FOA is best suited for teams proposing high-value, community-facing animal model resources or laboratory animal health tools that will clearly benefit multiple NIH research communities rather than advancing a single disease program in isolation.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Resource-Related Research Projects for Development of Animal Models and Related Materials (R24 Clinical Trials Not-Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
• This funding opportunity was created on 2022-09-09.
• Applicants must submit their applications by 2025-05-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA OD 22 013

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