Opportunity Information: Apply for RFA AI 19 025

The U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (Infectious Diseases) is an NIH funding opportunity (RFA-AI-19-025) that supports joint infectious disease research projects carried out through formal collaboration between NIH Intramural Research Program (IRP) scientists and investigators based in South Africa. It uses a cooperative agreement mechanism (U01), meaning NIH expects to have an active scientific partnership role during the project rather than simply providing funds with minimal involvement. Clinical trials are allowed but not required under this announcement ("Clinical Trial Optional"), so applicants can propose either non-clinical or clinical research as long as it fits the program goals.

The scientific scope focuses on high-priority infectious disease areas relevant to both countries and to global health. The FOA specifically highlights research on tuberculosis, sexually transmitted infections, parasitic infections, arboviruses, and emerging or re-emerging viral pathogens. It also explicitly includes vector biology and vector control, which broadens the opportunity beyond pathogen-focused laboratory work to include studies on the organisms that transmit disease (such as mosquitoes and other vectors) and strategies to reduce transmission.

A central requirement is that the project must be genuinely collaborative and balanced across partners. To be eligible, the application has to include at least one NIH IRP investigator serving as a Project Scientist, and that NIH scientist must have an equal role in the conceptualization, design, and execution of the research. In practice, this means the NIH intramural partner cannot be a minor consultant or peripheral contributor; the program is built around shared leadership and integrated scientific effort between NIH intramural laboratories/clinics and the South African research team.

On applicant eligibility, the FOA is structured so that the applying institution is non-U.S. and specifically South African. Non-domestic (non-U.S.) entities and foreign institutions can apply, but only those in South Africa that qualify as National Research Foundations (as defined in the FOA) are eligible to serve as the applicant organization. At the same time, non-domestic components of U.S. organizations are not eligible to apply as the applicant. However, foreign components are allowed under NIH policy, meaning a U.S. organization can have a foreign component involved in the project, but the application itself must meet the FOA's specific eligibility rules about who can be the primary applicant and how the U.S.-South Africa partnership is structured.

Administrative details included in the source information indicate it is an NIH discretionary funding opportunity in the health category (CFDA 93.855), created on March 15, 2019, with an original closing date of July 26, 2019. The listed award ceiling is $250,000. The expected number of awards is not provided in the supplied data. Overall, the opportunity is aimed at sustaining and expanding Phase 2 of an established U.S.-South Africa collaborative program by funding well-integrated teams that can jointly advance biomedical research on major infectious disease threats, with NIH intramural scientists embedded as full partners in the work.

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "U.S.-South Africa Program for Collaborative Biomedical Research - Phase 2 (Infectious Diseases) (U01 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855.
  • This funding opportunity was created on 2019-03-15.
  • Applicants must submit their applications by 2019-07-26. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $250,000.00 in funding.
  • Eligible applicants include: Others.
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Novel RNAs in Virology (including HIV) and Immune Regulation: Basic Science and Therapeutic Discovery (R21 Clinical Trial Not Allowed) Apply for PA 19 237

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