Opportunity Information: Apply for RFA CA 20 012

Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) is a National Cancer Institute (NCI) funding opportunity designed specifically for investigators who already hold an active NCI-funded U01 cooperative agreement and want to submit a revision to that ongoing project. The main goal is to help existing U01 research teams expand the scope of their original aims or speed up the pace and impact of the parent study by bringing in proven informatics approaches that were created through the NCI Informatics Technology for Cancer Research (ITCR) Program. In practice, this opportunity is meant to move ITCR-supported software, platforms, data resources, or computational methods off the shelf and into real cancer research workflows, where they can be tested, adapted, integrated, and used by the communities they were built to serve.

A key feature of the opportunity is its focus on adoption and integration rather than starting from scratch. The revision funding is intended to support new work that builds directly on the parent U01 project but adds an informatics component grounded in ITCR-developed tools or resources, whether those tools were supported by current or previous ITCR awards. The NCI is using this mechanism to encourage novel collaborations, especially interdisciplinary partnerships where cancer researchers and informatics developers or implementers work together. The underlying idea is that the parent U01 provides a strong, real-world research setting, and the ITCR technologies provide advanced informatics capabilities; combining them should accelerate discovery, improve rigor and reproducibility, and help ensure that informatics innovations are actually usable and used.

This is a discretionary federal funding opportunity issued by the Department of Health and Human Services (HHS) through the National Institutes of Health (NIH), with NCI as the sponsoring institute. The award mechanism is a cooperative agreement (U01), which generally means NIH staff expect to have substantial scientific or programmatic involvement compared to a standard research grant. Clinical trials are optional under this announcement, meaning applicants may propose clinical trial-related activities if they fit the scope and rules of the parent award and the revision, but a clinical trial is not required.

From a funding and scale standpoint, the announcement lists an award ceiling of $100,000 and anticipates making about 4 awards. That level of support signals that the revision is meant to be targeted and additive, such as enabling integration work, piloting an ITCR tool in the context of the parent study, extending a pipeline to accommodate the study's data types, improving interoperability, or otherwise removing practical barriers to using an existing informatics technology within an active cancer research project. The opportunity was created on January 23, 2020, with an original closing date of November 18, 2020.

Eligibility is broad across the kinds of organizations that can apply, including a wide range of government entities (state, county, city/township, special districts), public and private institutions of higher education, independent school districts, Native American tribal governments and organizations, public housing authorities/Indian housing authorities, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), small businesses, and other applicants as described in the announcement's additional eligibility language. Even with broad organizational eligibility, the practical eligibility constraint is that the application must be a revision to an existing, currently funded NCI U01 project, since the FOA is specifically aimed at revising active cooperative agreements rather than initiating new standalone projects.

Overall, the opportunity is best understood as a bridge between tool-building and tool-using in cancer research. NCI is encouraging teams with active U01 projects to bring ITCR-supported informatics innovations into their ongoing studies in a way that measurably expands the science or accelerates progress, while also strengthening collaboration between domain researchers and informatics specialists and increasing the real-world impact of ITCR program investments.

  • The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
  • This funding opportunity was created on Jan 23, 2020.
  • Applicants must submit their applications by Nov 18, 2020. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $100,000.00 in funding.
  • The number of recipients for this funding is limited to 4 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
Apply for RFA CA 20 012

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