Opportunity Information: Apply for RFA CA 19 020
The grant opportunity titled "Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed)" is a National Cancer Institute (NCI) funding announcement under the NIH (HHS) that supports exploratory but advanced-stage technology development projects. The core purpose is to move promising, newer molecular and cellular analysis technologies closer to broad research use by funding the next wave of development and rigorous validation work. It is specifically aimed at technologies that can target, probe, or assess molecular and cellular features that matter in cancer biology, in ways that existing tools cannot do as well or cannot do at all.
This FOA uses the R33 mechanism, which is generally meant for projects that have already cleared the most basic feasibility hurdles. Applicants are expected to have supportive preliminary data showing that the technology or method is workable in principle and that key feasibility gaps have been addressed. At the same time, the technology is not considered ready for widespread adoption yet, so the proposal should focus on what still needs to be engineered, optimized, standardized, and validated so that other researchers can confidently use it. The emphasis is on careful development and validation, not simply demonstrating the technology in one lab under ideal conditions. Reviewers are looking for credible plans to prove performance, reliability, reproducibility, and practical utility.
The technologies supported can be relevant to both basic and clinical cancer research, as long as the work centers on improving molecular and/or cellular characterization of cancer. The announcement highlights a wide range of cancer-related research areas that could benefit, including cancer biology, early detection and screening, clinical diagnosis, treatment, cancer control, epidemiology, and work that addresses cancer health disparities. In practical terms, a well-aligned project would show how the technology could accelerate research or make it more informative, for example by enabling new kinds of measurements, improving sensitivity or specificity, capturing heterogeneity at the single-cell level, mapping spatial context in tissues, improving molecular profiling from limited material, or otherwise expanding what can be measured about tumors and their microenvironments.
A key boundary in this FOA is that it is not meant to fund projects where the technology is already established and the only new element is the biological question, disease context, or clinical target being studied. If the novelty is mainly the cancer type, biomarker, pathway, or clinical cohort rather than the analytical technology itself, the application is considered out of scope and will not be reviewed. The innovation must be in the emerging technology or methodology and in how it advances molecular and cellular analysis capabilities for cancer research, not merely in what it is applied to.
Clinical trials are explicitly not allowed under this announcement, which means applicants cannot propose prospective interventional studies that meet NIH definitions of a clinical trial. That said, the technology development may still be highly relevant to clinical research and could include validation using clinical specimens or clinically annotated samples, depending on the specific NIH policies and the study design, as long as it does not cross into a clinical trial.
From an administrative standpoint, this is a discretionary grant opportunity (Funding Opportunity Number RFA-CA-19-020) associated with CFDA 93.394. The award ceiling listed is $300,000, with an expected 10 awards. The original posting date is January 7, 2019, and the original closing date is September 27, 2019. Eligibility is broad and includes many organization types such as state, county, and local governments; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; independent school districts; special district governments; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); small businesses; and other eligible applicants as clarified in the full announcement.
Finally, the FOA sits within NCI's broader Innovative Molecular Analysis Technologies (IMAT) Program, which is designed to stimulate the creation, refinement, and dissemination of next-generation measurement tools for cancer research. In that context, a strong application typically reads like a technology-focused development and validation plan with clear performance metrics, benchmarking against current methods, attention to robustness and usability, and a realistic pathway toward making the tool adoptable by the wider cancer research community.Apply for RFA CA 19 020
- The Department of Health and Human Services, National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advanced Development and Validation of Emerging Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R33 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.394.
- This funding opportunity was created on Jan 07, 2019.
- Applicants must submit their applications by Sep 27, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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| Funding Opportunity |
|---|
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 19 019 Funding Number: RFA CA 19 019 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P50 Clinical Trial Optional) Apply for RFA CA 19 027 Funding Number: RFA CA 19 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U54 Clinical Trials Optional) Apply for RFA CA 19 025 Funding Number: RFA CA 19 025 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (P01 Clinical Trial Optional) Apply for RFA CA 19 026 Funding Number: RFA CA 19 026 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (R01 Clinical Trial Optional) Apply for RFA CA 19 023 Funding Number: RFA CA 19 023 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Revisions for Incorporation of Novel NCI- Supported Technology to Accelerate Cancer Research (U01 Clinical Trial Optional) Apply for RFA CA 19 024 Funding Number: RFA CA 19 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
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| Feasibility and Planning Studies for Development of Specialized Programs of Research Excellence (SPOREs) to Investigate Cancer Health Disparities (P20 Clinical Trial Optional) Apply for RFA CA 19 034 Funding Number: RFA CA 19 034 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $800,000 |
| Optimizing the Management and Outcomes for Cancer Survivors Transitioning to Follow-up Care (R01 Clinical Trial Required) Apply for RFA CA 19 035 Funding Number: RFA CA 19 035 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| American Schools and Hospitals Abroad Program Worldwide Apply for 72ASHA19RFA00001 Funding Number: 72ASHA19RFA00001 Agency: Agency for International Development Category: Education, Health Funding Amount: $2,000,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (R01 Clinical Trials Optional) Apply for RFA CA 19 062 Funding Number: RFA CA 19 062 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U01 Clinical Trials Optional) Apply for RFA CA 19 061 Funding Number: RFA CA 19 061 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Revision Applications to Support the Application of Informatics Technology for Cancer Research (U24 Clinical Trials Optional) Apply for RFA CA 19 063 Funding Number: RFA CA 19 063 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| The National Drug Abuse Treatment Clinical Trials Network (UG1 Clinical Trial Required) Apply for RFA DA 20 024 Funding Number: RFA DA 20 024 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Limited Competition: Pediatric Brain Tumor Consortium (UM1 Clinical Trials Required) Apply for RFA CA 19 059 Funding Number: RFA CA 19 059 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,300,000 |
| Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Data Coordination, Analysis, and Scientific Outreach (UM1 Clinical Trial Not Allowed) Apply for RFA DA 20 027 Funding Number: RFA DA 20 027 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Limited Competition: Biospecimen Banks to support NCI National Clinical Trials Network (NCTN)(U24 Clinical Trial Not Allowed) Apply for RFA CA 20 002 Funding Number: RFA CA 20 002 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $3,000,000 |
| Communication and Decision Making for Individuals with Inherited Cancer Syndromes (U01 Clinical Trial Optional) Apply for RFA CA 20 006 Funding Number: RFA CA 20 006 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21 Clinical Trials Not Allowed) Apply for RFA CA 20 017 Funding Number: RFA CA 20 017 Agency: Department of Health and Human Services, National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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