Support of NIGMS Program Project Grants (P01) | PAR 16 433

Opportunity Information: Apply for PAR 16 433

The Support of NIGMS Program Project Grants (P01) funding opportunity (PAR-16-433) is a National Institutes of Health (NIH) discretionary grant run through the National Institute of General Medical Sciences (NIGMS) in the health funding area (CFDA 93.859). It is designed specifically for large, collaborative research efforts that tackle an important biological problem aligned with the NIGMS mission. The central idea is that a Program Project (P01) should bring together multiple investigators and multiple related research projects in a coordinated way, where the projects are genuinely interdependent and benefit from being funded and managed as a single, integrated program rather than as separate, stand-alone R01-style grants.

A key feature of this opportunity is its emphasis on innovation and interaction. Applicants are expected to propose a set of connected projects led by outstanding scientists who can demonstrate that working together creates clear scientific advantages, such as shared intellectual frameworks, complementary expertise, coordinated experimental strategies, and efficiencies that would be difficult to achieve if each project were funded independently. In practice, this means the overall application should be organized around one significant, clearly articulated biological question or challenge, with each component project contributing a necessary piece of the solution and reinforcing the others. The expectation is not simply “several good projects under one umbrella,” but rather a coherent research program where integration is essential to the science.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (as long as they are not institutions of higher education, since those are listed separately); for-profit organizations other than small businesses; and small businesses. The announcement also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.

Foreign eligibility is restricted in a way that is common for many NIH mechanisms. Non-domestic (non-U.S.) entities (foreign organizations) and non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply under this FOA. However, “foreign components” are allowed when they meet the NIH Grants Policy Statement definition, meaning a U.S. applicant can include certain scientifically justified international activities or collaborations as part of the proposed work, as long as the applicant organization itself is eligible and the foreign involvement fits NIH policy requirements.

From the funding details provided, the listed award ceiling is $6,500,000, indicating this mechanism can support relatively large-scale, multi-project research programs. The opportunity was created on September 12, 2016, and the original closing date listed is September 22, 2017. The announcement does not specify the number of expected awards in the provided data, but the structure and ceiling make clear that it is intended for substantial, coordinated programs rather than single-lab efforts. Overall, this FOA is best suited for institutions assembling a tightly integrated team with a compelling, shared scientific objective where the collaborative structure is necessary to make progress on a major biological problem within the NIGMS scope.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Support of NIGMS Program Project Grants (P01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
• This funding opportunity was created on 2016-09-12.
• Applicants must submit their applications by 2017-09-22. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $6,500,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 16 433

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