Primary Care-Based Screening and Intervention Development for Prevention of Abuse in Older and Vulnerable Adults in the Context of Alzheimers Disease and Related Dementias (R61/R33 Clinical Trial Required) | RFA AG 22 024

Opportunity Information: Apply for RFA AG 22 024

The grant opportunity titled "Primary Care-Based Screening and Intervention Development for Prevention of Abuse in Older and Vulnerable Adults in the Context of Alzheimers Disease and Related Dementias (R61/R33 Clinical Trial Required)" (Funding Opportunity Number RFA-AG-22-024) is a discretionary NIH research grant focused on protecting older and vulnerable adults who are at heightened risk of abuse because of mild cognitive impairment (MCI) or Alzheimers disease and related dementias (AD/ADRD). The core purpose is to fund research that produces practical, evidence-based tools and approaches that can be used in primary care settings, where many older adults and families regularly interact with the health system and where early warning signs of mistreatment may be detected.

This FOA is centered on two connected development goals. First, it supports the creation and refinement of primary care-based screening tools that can identify abuse risk or ongoing abuse among patients with MCI or AD/ADRD. Second, it supports the development of behavioral interventions designed to prevent abuse and reduce harm for these at-risk adults and their families. The emphasis on primary care signals a clear interest in solutions that are feasible in real-world clinical workflows, sensitive to the complexities of cognitive impairment, and capable of being implemented at the point where patients and caregivers often seek routine medical guidance.

The funding mechanism is the R61/R33 phased innovation structure, and a clinical trial is required. In general terms, this kind of phased approach is intended to move projects from early-stage development and testing (R61) into a later stage that expands and confirms the approach (R33), with clear milestones expected between phases. In practice, applicants are expected to propose a research plan that not only designs or adapts screening and intervention components, but also evaluates them through clinical trial methods so the end products are more than conceptual and can be supported by evidence.

The opportunity is administered by the National Institutes of Health under the health research activity category, with CFDA number 93.866. The original closing date listed for the opportunity is 2021-10-20, and the posting creation date is 2021-07-15. An explicit award ceiling and the expected number of awards are not specified in the provided source data, which usually means prospective applicants would need to consult the full announcement or related NIH documentation for budget and award expectations.

Eligibility is broad and intentionally inclusive, spanning many types of organizations that could contribute to intervention development and clinical research in healthcare and community contexts. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations (including those other than federally recognized governments); public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations other than small businesses; and small businesses. The FOA also highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal government agencies, regional organizations, U.S. territories or possessions, and even non-domestic (non-U.S.) entities and foreign organizations. This wide eligibility list reflects the reality that preventing abuse in dementia contexts often requires collaboration among clinical providers, researchers, social services, and community partners, and may benefit from culturally grounded approaches.

Overall, the FOA is aimed at generating actionable, tested screening and prevention strategies that primary care practices can use to better protect cognitively vulnerable older adults and to support families navigating the stresses and risks associated with MCI and AD/ADRD. The emphasis on evidence-based development, clinical trial evaluation, and deployable primary care tools suggests a strong preference for projects that can move from research to practical adoption, improving detection of abuse risk and strengthening prevention efforts in everyday healthcare settings.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Primary Care-Based Screening and Intervention Development for Prevention of Abuse in Older and Vulnerable Adults in the Context of Alzheimers Disease and Related Dementias (R61/R33 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2021-07-15.
• Applicants must submit their applications by 2021-10-20. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA AG 22 024

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