Opportunity Information: Apply for HT9425 23 TBIPHRP IIRA
The DoD Traumatic Brain Injury and Psychological Health, Investigator-Initiated Research Award (FY23 TBIPHRP IIRA; Funding Opportunity Number HT9425-23-TBIPHRP-IIRA) is a Department of Defense research funding opportunity aimed at advancing the science and practice around traumatic brain injury (TBI) and psychological health conditions. The program is looking for investigator-driven projects that can make a meaningful contribution to understanding, preventing, assessing, or treating these conditions, especially where there is a clear and important gap in knowledge or patient care. The overall emphasis is on research that can move the field forward in practical ways, with applicants expected to spell out both near-term and long-term outcomes or products, whether those outputs are new knowledge, tools, methods, protocols, or other tangible deliverables that could ultimately improve care.
The scope of work supports applied and translational research, which can include preclinical work in animal models, studies in human subjects, and correlative studies that link to an existing clinical trial. A key boundary is that this award cannot be used to conduct a clinical trial. In this announcement, a clinical trial is defined in the standard way: a study where human subjects are prospectively assigned to one or more interventions (including placebo or controls) to evaluate the effects on biomedical or behavioral outcomes. That means applicants can still do human research, and they can work with human anatomical substances, but they need to design the project so it does not cross into testing an intervention for safety, efficacy, or effectiveness. Observational studies, mechanistic studies, biomarker work, validation of assessments, and other non-interventional human studies can fit, as can analyses that are correlative to an already-running clinical trial (as long as the proposed work is not itself the trial).
A major theme of the FY23 TBIPHRP is improving real-world impact by collaborating with the communities most affected by TBI and psychological health conditions, including people with lived experience, families, and care providers. The program encourages, but does not require, Community-Based Participatory Research (CBPR) approaches, particularly when human subjects are involved. CBPR is framed as a way to build equitable partnerships where community members and researchers share responsibility across the research lifecycle, from identifying needs and shaping study design to interpreting results and disseminating findings back to the community. The announcement also highlights that CBPR can be especially important for community-level interventions and for conditions that disproportionately affect health disparity populations. Practical examples of acceptable collaboration models include lived experience consultation (having at least one team member with lived experience who advises throughout the project), partnerships with community-based organizations that can provide ongoing input, and community advisory boards that bring multiple stakeholders together. One notable rule is that CBPR team members cannot be employees of any organization participating in the application, reinforcing the idea that community partners should be independent voices rather than internal staff. When used, CBPR participation can be documented through letters of commitment and a CBPR statement in specified application attachments.
The opportunity also includes an Early-Career Investigator Partnering Option designed to promote meaningful collaborations and support career development while strengthening the science. Under this option, an application can name two principal investigators: an Initiating PI (who handles most administrative submission responsibilities) and a Partnering PI. One of the two must qualify as an Early-Career Investigator, and the application should make a clear case that the partnership is essential, explaining what distinct expertise each PI contributes and why the work is stronger together than as separate projects. If selected for funding, each PI is expected to receive an individual award within their respective recipient organization, reflecting a true partnered structure rather than a single-PI award with a minor collaborator.
From an administrative and funding perspective, the agency is the Department of Defense (Department of the Army, USAMRAA), the assistance listing is CFDA 12.420, and eligibility is described as unrestricted (open broadly to entity types, subject to any specific clarifications in the full notice). The mechanism listed includes grants and cooperative agreements. The anticipated direct costs for the full period of performance are capped at $500,000. The announcement projected about 14 awards, with awards to be made no later than September 30, 2024. The original posting and deadline information provided indicates the opportunity was created April 27, 2023, with an original closing date of July 6, 2023.Apply for HT9425 23 TBIPHRP IIRA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Traumatic Brain Injury and Psychological Health, Investigator-Initiated Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Apr 27, 2023.
- Applicants must submit their applications by Jul 06, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 14 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Frequently Asked Questions (FAQs)
What is the FY23 TBIPHRP Investigator-Initiated Research Award (IIRA)?
The FY23 Traumatic Brain Injury and Psychological Health, Investigator-Initiated Research Award (TBIPHRP IIRA) is a Department of Defense research funding opportunity that supports investigator-driven projects intended to advance the science and practice related to traumatic brain injury (TBI) and psychological health conditions.
What is the official funding opportunity number for this grant?
The Funding Opportunity Number is HT9425-23-TBIPHRP-IIRA.
Which agency is offering this opportunity?
This opportunity is offered by the Department of Defense (DoD), with the Department of the Army (USAMRAA) identified as the agency administering the award.
What is the Assistance Listing (CFDA) number?
The Assistance Listing (CFDA) number is 12.420.
What kinds of projects is the program looking for?
The program seeks investigator-initiated research projects that make a meaningful contribution to understanding, preventing, assessing, or treating TBI and psychological health conditions, particularly where there is a clear and important gap in knowledge or patient care.
What is the overall emphasis or goal of the research?
The emphasis is on applied and translational research that can move the field forward in practical ways. Applicants are expected to describe near-term and long-term outcomes or products, such as new knowledge, tools, methods, protocols, or other tangible deliverables that could ultimately improve care.
What types of research approaches are within scope?
The scope supports applied and translational research approaches, including preclinical work in animal models, studies in human subjects, and correlative studies linked to an existing clinical trial.
Are clinical trials allowed under this award?
No. This award cannot be used to conduct a clinical trial.
How does this announcement define a clinical trial?
A clinical trial is defined as a study in which human subjects are prospectively assigned to one or more interventions (including placebo or controls) to evaluate the effects on biomedical or behavioral outcomes.
Can an application include human subjects research?
Yes. Human subjects research may be included as long as the proposed work does not cross into a clinical trial (for example, it should not prospectively assign participants to an intervention to evaluate outcomes).
Are observational or mechanistic human studies allowed?
Yes. Observational studies, mechanistic studies, biomarker work, validation of assessments, and other non-interventional human studies can fit within the scope, based on the information provided.
Can the award support work involving human anatomical substances?
Yes. The announcement indicates applicants can work with human anatomical substances, provided the project is designed so it does not become a clinical trial.
What does it mean to do correlative work tied to an existing clinical trial?
The program allows studies that are correlative to an already-running clinical trial, as long as the proposed work is not itself the clinical trial.
Is collaboration with affected communities encouraged?
Yes. A major theme is improving real-world impact by collaborating with communities affected by TBI and psychological health conditions, including people with lived experience, families, and care providers.
Is Community-Based Participatory Research (CBPR) required?
No. CBPR approaches are encouraged but not required, particularly when human subjects are involved.
What is CBPR in the context of this opportunity?
CBPR is described as an approach that builds equitable partnerships where community members and researchers share responsibility across the research lifecycle, including identifying needs, shaping study design, interpreting results, and disseminating findings back to the community.
When might CBPR be especially important?
The announcement notes CBPR can be especially important for community-level interventions and for conditions that disproportionately affect health disparity populations.
What are examples of acceptable community collaboration models?
Examples provided include lived experience consultation (with at least one team member with lived experience who advises throughout the project), partnerships with community-based organizations that provide ongoing input, and community advisory boards that include multiple stakeholders.
Are there restrictions on who can serve as a CBPR team member?
Yes. CBPR team members cannot be employees of any organization participating in the application, to help ensure community partners serve as independent voices rather than internal staff.
How is CBPR participation documented in an application (if used)?
When used, CBPR participation can be documented through letters of commitment and a CBPR statement in specified application attachments.
What is the Early-Career Investigator Partnering Option?
It is an option intended to promote meaningful collaborations and support career development while strengthening the science by allowing an application to name two principal investigators working as true partners.
How many principal investigators can be named under the partnering option?
Two principal investigators can be named: an Initiating PI and a Partnering PI.
What is the role of the Initiating PI?
The Initiating PI handles most administrative submission responsibilities for the application.
Does one of the PIs have to be an Early-Career Investigator?
Yes. Under the partnering option, one of the two PIs must qualify as an Early-Career Investigator.
What must the application explain about the PI partnership?
The application should clearly justify why the partnership is essential, describe the distinct expertise each PI contributes, and explain why the work is stronger together than as separate projects.
How are awards structured if the partnering option is funded?
If selected for funding, each PI is expected to receive an individual award within their respective recipient organization, reflecting a partnered structure rather than a single-PI award with a minor collaborator.
What award mechanisms are associated with this opportunity?
The mechanisms listed include grants and cooperative agreements.
What is the maximum budget allowed?
Anticipated direct costs for the full period of performance are capped at $500,000.
How many awards were projected?
The announcement projected approximately 14 awards.
When were awards expected to be made by?
Awards were projected to be made no later than September 30, 2024.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning it is open broadly to entity types, subject to any specific clarifications in the full notice.
When was the opportunity posted and when did it close?
The opportunity was created on April 27, 2023, with an original closing date of July 6, 2023.
What kinds of deliverables or outputs does the program expect applicants to describe?
Applicants are expected to spell out near-term and long-term outcomes or products, which may include new knowledge, tools, methods, protocols, or other tangible deliverables intended to improve care over time.
Does the program prioritize projects addressing specific needs?
Based on the information provided, the program prioritizes projects that address clear and important gaps in knowledge or patient care and that are positioned to have real-world impact.
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