Opportunity Information: Apply for RFA DA 22 012
Assessing the Effects of Cannabinoids on HIV-Associated Persistent Inflammation (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number RFA-DA-22-012) that supports research aimed at clarifying how cannabinoids and the endocannabinoid system influence persistent inflammation in people with HIV, and how that ongoing inflammation may affect nervous system function. The central emphasis is on identifying biological mechanisms, with the announcement explicitly encouraging basic science and preclinical studies rather than focusing solely on clinical outcomes. In practical terms, the FOA is looking for projects that can move beyond broad associations and instead explain the pathways, targets, and processes through which cannabinoid-related compounds or signaling systems might alter inflammatory biology in the context of HIV, and how those inflammatory changes may connect to neurological or neurobehavioral consequences.
A key feature of this opportunity is that applications must bring together expertise and resources from both HIV/AIDS research and addiction science. That requirement reflects the intersection this FOA is trying to address: cannabinoids are commonly used substances with relevance to addiction research, while HIV-associated chronic inflammation remains an important driver of long-term complications even in the era of effective antiretroviral therapy. Competitive projects would be expected to integrate these domains in a meaningful way, for example by using established HIV-related inflammatory models while also incorporating rigorous cannabinoid science (such as cannabinoid receptor biology, endocannabinoid metabolism, or exposure paradigms relevant to real-world use). The title notes "Clinical Trial Optional," indicating that applicants may propose a clinical trial if it is appropriate for the science, but a clinical trial is not required; the primary intent is mechanistic work that strengthens biological understanding.
The award mechanism is the R01 research project grant, a common NIH funding instrument designed for substantial, hypothesis-driven research programs. The activity areas listed for this opportunity fall under education and health, and the CFDA number associated with it is 93.279. The original closing date for the competition was August 5, 2021, and the posting indicates no specified award ceiling and does not list an expected number of awards in the provided summary fields, meaning applicants would typically need to consult the full FOA text for budget limits, project period guidance, and any institute-specific funding plans.
Eligibility is broad and includes many categories of domestic organizations and governments, reflecting NIH norms for investigator-initiated research. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other unspecified entities that NIH may allow under its general eligibility rules. The FOA also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal government agencies; faith-based or community-based organizations; U.S. territories or possessions; regional organizations; and non-domestic (non-U.S.) entities, meaning foreign organizations may apply as well.
Overall, this funding opportunity is designed for research teams capable of bridging cannabinoid biology, addiction science, and HIV-related immunology and neurology to explain how cannabinoid exposure or endocannabinoid signaling may shape persistent inflammatory states associated with HIV and what those changes mean for nervous system function. Applicants are expected to propose mechanistic, well-justified studies with the expertise to address both the HIV/AIDS and addiction dimensions, using approaches that can credibly uncover causal pathways rather than simply describing correlations.Apply for RFA DA 22 012
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Assessing the Effects of Cannabinoids on HIV-Associated Persistent Inflammation (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2021-05-24.
- Applicants must submit their applications by 2021-08-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Assessing the Effects of Cannabinoids on HIV-Associated Persistent Inflammation (R01 Clinical Trial Optional)."
Who is offering this funding opportunity?
This is a discretionary grant opportunity from the National Institutes of Health (NIH).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA-DA-22-012.
What is the main scientific goal of this FOA?
The central goal is to clarify how cannabinoids and the endocannabinoid system influence persistent inflammation in people with HIV, and how that ongoing inflammation may affect nervous system function. The emphasis is on identifying biological mechanisms, pathways, targets, and processes rather than describing broad associations.
What does the FOA mean by "persistent inflammation" in the context of HIV?
Based on the description provided, the FOA is focused on chronic or ongoing inflammatory biology associated with HIV, including inflammation that remains important even in the era of effective antiretroviral therapy, and how that persistent inflammatory state relates to longer-term complications.
How do cannabinoids fit into the focus of this HIV-related inflammation FOA?
The FOA is looking at how cannabinoid-related compounds or cannabinoid/endocannabinoid signaling systems may alter inflammatory biology in the context of HIV, and how those inflammation-related changes may connect to neurological or neurobehavioral consequences.
Is the FOA focused on clinical outcomes or mechanistic science?
The description explicitly emphasizes biological mechanisms and encourages basic science and preclinical studies, rather than focusing solely on clinical outcomes.
Are clinical trials required?
No. The title includes "Clinical Trial Optional," meaning a clinical trial may be proposed if appropriate, but a clinical trial is not required.
If clinical trials are optional, what kind of projects does the FOA primarily want?
The primary intent described is mechanistic work that strengthens biological understanding, moving beyond correlations to explain causal pathways, targets, and processes linking cannabinoids/endocannabinoid signaling with HIV-associated persistent inflammation and nervous system effects.
What kinds of approaches are encouraged by this FOA?
The announcement encourages studies that go beyond broad associations and instead explain mechanisms. It also explicitly encourages basic science and preclinical studies and highlights rigorous cannabinoid science such as cannabinoid receptor biology, endocannabinoid metabolism, and exposure paradigms relevant to real-world use, integrated with established HIV-related inflammatory models.
Is there a special expertise requirement for applicant teams?
Yes. Applications must bring together expertise and resources from both HIV/AIDS research and addiction science, reflecting the intersection the FOA is designed to address.
Why does the FOA require both HIV/AIDS and addiction science expertise?
The FOA targets an intersection: cannabinoids are commonly used substances with relevance to addiction research, while HIV-associated chronic inflammation remains an important driver of long-term complications. Competitive projects are expected to integrate these domains meaningfully.
What is the funding mechanism for this opportunity?
The award mechanism is an R01 research project grant.
What does an R01 mechanism generally imply for the type of project?
In this description, the R01 is characterized as a common NIH funding instrument designed for substantial, hypothesis-driven research programs.
What activity areas does this opportunity fall under?
The activity areas listed are education and health.
What is the CFDA number associated with this opportunity?
The CFDA number provided is 93.279.
When was the original closing date for the competition?
The original closing date listed is August 5, 2021.
Is there an award ceiling listed in the provided summary?
No. The provided summary indicates there is no specified award ceiling.
Does the provided summary list the expected number of awards?
No. The provided summary fields do not list an expected number of awards.
Where should applicants look for budget limits, project period guidance, or funding plans?
The description indicates applicants would typically need to consult the full FOA text for details such as budget limits, project period guidance, and any institute-specific funding plans.
Who is eligible to apply?
Eligibility is described as broad and includes many categories of domestic organizations and governments, as well as non-domestic (non-U.S.) entities. The eligible categories listed include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other unspecified entities NIH may allow under general eligibility rules.
Are minority-serving institutions included in eligibility?
Yes. The FOA highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs).
Can federal agencies apply?
Yes. The eligibility list includes eligible federal government agencies.
Can faith-based or community-based organizations apply?
Yes. The eligibility list includes faith-based or community-based organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility list includes U.S. territories or possessions.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA states that non-domestic (non-U.S.) entities may apply as well.
What would make a project competitive based on the description provided?
Based on the provided description, competitive projects would integrate HIV-related inflammatory models with rigorous cannabinoid science, include meaningful expertise from both HIV/AIDS research and addiction science, and propose mechanistic, well-justified studies capable of uncovering causal pathways rather than simply reporting correlations. Projects should also address how inflammation changes may connect to nervous system function and related neurological or neurobehavioral consequences.
Does the FOA prioritize explaining mechanisms over reporting associations?
Yes. The description emphasizes moving beyond broad associations to explain pathways, targets, and biological processes through which cannabinoid exposure or endocannabinoid signaling may alter inflammation in HIV and how those changes may affect the nervous system.
What is the overall purpose of this funding opportunity in one sentence?
Overall, the opportunity is designed for research teams that can bridge cannabinoid biology, addiction science, and HIV-related immunology/neurology to explain how cannabinoid exposure or endocannabinoid signaling may shape HIV-associated persistent inflammatory states and what that means for nervous system function.
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| The Early Detection Research Network: Clinical Validation Centers (U01 Clinical Trial Optional) Apply for RFA CA 21 033 Funding Number: RFA CA 21 033 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Early Detection Research Network: Data Management and Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 034 Funding Number: RFA CA 21 034 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed) Apply for RFA CA 21 035 Funding Number: RFA CA 21 035 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Method to Extend Research in Time (MERIT) Award Extension Request (Type 4 Clinical Trial Optional) Apply for PAR 21 138 Funding Number: PAR 21 138 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory Studies to Investigate the Mechanisms of Interrelationship Between Sleep and Substance Use Disorders (R61/R33 Clinical Trials Not Allowed) Apply for RFA DA 22 016 Funding Number: RFA DA 22 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Data Analysis Resource (U24 Clinical Trials Optional) Apply for RFA AA 21 009 Funding Number: RFA AA 21 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Research Project Sites (U01 Clinical Trials Optional) Apply for RFA AA 21 007 Funding Number: RFA AA 21 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA) Administrative Resource (U24 Clinical Trials Optional) Apply for RFA AA 21 008 Funding Number: RFA AA 21 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed) Apply for PAR 21 244 Funding Number: PAR 21 244 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Innovative Models for Delivering PrEP and STI Services to Stop HIV in the United States (R61/R33 Clinical Trial Optional) Apply for RFA AI 20 069 Funding Number: RFA AI 20 069 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| PrEP for HIV Prevention among Substance Using Populations (R01 - Clinical Trial Optional) Apply for RFA DA 22 017 Funding Number: RFA DA 22 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Organoid Modeling of Neural Stimulants and HIV Comorbidity of Human Brain (R01- Clinical Trial Optional) Apply for RFA DA 22 009 Funding Number: RFA DA 22 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Large Scale Mapping and/or Molecular Profiling of Ensembles and/or Cell-Types Mediating Opioid Action in the Rodent Brain (R01 - Clinical Trial Not Allowed) Apply for RFA DA 22 011 Funding Number: RFA DA 22 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Elucidating the Effects of ART on Neuronal Function in the Context of SUD and HIV (R01 - Clinical Trials Not Allowed) Apply for RFA DA 22 003 Funding Number: RFA DA 22 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Radiation Oncology-Biology Integration Network (ROBIN) Centers (U54 Clinical Trial Required) Apply for RFA CA 21 040 Funding Number: RFA CA 21 040 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Understanding Oral Human Papillomavirus (HPV) Infection, Acquisition, and Persistence in People Living with HIV (R21 Clinical Trial Not Allowed) Apply for RFA DE 22 004 Funding Number: RFA DE 22 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Program on the Origins of Gastroesophageal Cancers (R01 Clinical Trial Optional) Apply for RFA CA 21 026 Funding Number: RFA CA 21 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Coordinating Center for the Program on the Origins of Gastroesophageal Cancers (U24 Clinical Trial Not Allowed) Apply for RFA CA 21 027 Funding Number: RFA CA 21 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Exploratory Studies to Investigate the Mechanisms of Interrelationship between Sleep and Substance Use Disorders (R61/R33 Basic Experimental Studies with Humans Required) Apply for RFA DA 22 029 Funding Number: RFA DA 22 029 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Understanding Oral Human Papillomavirus (HPV) Infection, Acquisition, and Persistence in People Living with HIV (R01 Clinical Trial Not Allowed) Apply for RFA DE 22 003 Funding Number: RFA DE 22 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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