Opportunity Information: Apply for RFA DA 24 028
Advancing Psychedelics Research for Treating Addiction (R01 Clinical Trial Not Allowed) is a National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) grant opportunity focused on basic and preclinical mechanistic research that can clarify how psychedelic compounds might be leveraged to address substance use disorders (SUDs) and closely related psychiatric or neurological co-morbidities. The central purpose is not to run clinical trials, but to push the science forward on what psychedelics are doing in the brain and body at multiple levels of analysis, including molecular signaling, cellular responses, neural circuit function, and structural or systems-level changes that may be relevant to addictive drug effects and addiction-related behaviors.
A key emphasis of the NOFO is elucidation and validation of mechanisms and pathways. In practice, this means projects are expected to go beyond descriptive findings and work toward establishing causal or well-supported links between specific psychedelic-modulated targets or pathways and addiction-relevant phenotypes. The opportunity explicitly highlights work that can identify common biological targets or converging pathways shared between psychedelics and the neurobiology of addiction, with the intent that funded research leads to transformative advances in understanding and, ultimately, therapeutic development. The scope includes mechanistic studies that connect psychedelic pharmacology to changes in reward, stress, craving, withdrawal, relapse vulnerability, learning and memory processes tied to substance use, and other phenotypes that directly influence addictive drug taking or seeking.
The announcement also encourages the design and synthesis of chemical probes as a supported research direction. These probes can be used to interrogate specific receptors, signaling cascades, cell types, or circuit elements that psychedelics influence, helping researchers precisely map which biological components are necessary or sufficient for observed effects. This can include creating or optimizing compounds that isolate certain pharmacological properties, developing tools that improve target engagement studies, or generating probe molecules that clarify mechanism-of-action questions that are difficult to answer with currently available substances. Overall, the expectation is that the tools and mechanistic insights generated will be broadly useful to the addiction research community, not just to a single compound or a single experimental model.
The funding mechanism is an NIH R01 grant (research project grant), and the listing states "Clinical Trial Not Allowed," which signals that applications should not propose human clinical efficacy or interventional clinical trials under this solicitation. The opportunity is categorized as discretionary grant funding within the education and health activity area and is associated with CFDA number 93.279. The funding opportunity number is RFA-DA-24-028. The source information provided lists an award ceiling of $350,000 (as presented in the data) and shows an original closing date of 2023-11-02, with a creation date of 2023-05-16.
Eligibility is broad and includes many typical NIH applicant organizations, spanning state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in those categories as stated); for-profit organizations (other than small businesses); and small businesses. The NOFO also calls out additional eligible applicants and institution types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). This breadth is intended to invite a wide range of scientific teams and institutional settings to contribute to the mechanistic science base for psychedelics in addiction, including organizations with strong community ties or specialized research capabilities.
In short, this NOFO is designed to fund rigorous, mechanistically oriented research that explains how psychedelics act on biological systems relevant to addiction, develops and applies chemical tools to interrogate those mechanisms, and produces knowledge that can reshape the field by directly informing addiction biology and future therapeutic strategies, while explicitly excluding clinical trials from the supported activity under this particular announcement.Apply for RFA DA 24 028
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Advancing Psychedelics Research for Treating Addiction (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2023-05-16.
- Applicants must submit their applications by 2023-11-02. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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|---|
| Advancing Psychedelics Research for Treating Addiction (R61/R33 Clinical Trial Required) Apply for RFA DA 24 024 Funding Number: RFA DA 24 024 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Advancing Psychedelics Research for Treating Addiction (R61/R33 Basic Experimental Study with Humans Required) Apply for RFA DA 24 029 Funding Number: RFA DA 24 029 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Emergency Medicine Research Career Development Program in the Neurological Sciences (EMRCDP-NS) (K12 - No Independent Clinical Trial Allowed) Apply for PAR 23 151 Funding Number: PAR 23 151 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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| Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R43/R44 Clinical Trial Optional) Apply for RFA DA 24 018 Funding Number: RFA DA 24 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $295,924 |
| Field-Deployable, Low-Cost Point-of-Need Approaches and Technologies to Lower the Barriers to Substance Use Disorders (SUD) Diagnosis and Treatment (R41/R42 Clinical Trial Optional) Apply for RFA DA 24 017 Funding Number: RFA DA 24 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: $295,924 |
| Accelerating Behavioral and Social Science through Ontology Development and Use: Research Network Projects (U01 Clinical Trial Not Allowed) Apply for PAR 23 182 Funding Number: PAR 23 182 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
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| Limited Competition: NIH-DoD-VA Pain Management Collaboratory - Coordinating Center (U24 Clinical Trial Not Allowed) Apply for RFA AT 24 002 Funding Number: RFA AT 24 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,300,000 |
| ADVANCE Predoctoral T32 Training Program to Promote Diversity in Health Disparities Research, Preventive Interventions, and Methodology (T32, Clinical Trial Not Allowed) Apply for RFA OD 23 018 Funding Number: RFA OD 23 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| PHS 2023-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required) Apply for PA 23 231 Funding Number: PA 23 231 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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